serologic evaluation of celiac disease in patients with beta thalassemia major and control

abstract introduction : celiac disease (cd) is an autoimmune disorder triggered by ingestion of gluten in genetically predisposed individuals.  this study reports evaluated prevalence of cd in patients with beta-thalassemia major. materials and methods: in this case-control study in a period of 3 years  which was performed on 620 children in two groups of  beta-thalassemia major  patients (n=200) and control (n=420), serum tissue transglutamianse (ttg) iga levels were measured. the two groups were compared together in terms of ttg iga levels, and p<0.05 was considered significant. results : the means of serum ttg iga levels in patients with beta-thalassemia major and control groups were 28.81±68.44 and 6.94±6.68 u/ml, respectively, there was a significant difference in favor of the case group (p=0.000). body mass index in the two case and control groups had a significant difference (t=3.859, p=0.001).  belonging to each group will change the probability of having less than 20 in ttg iga (odds=0.285) and it means that belonging to the control group has a protective role. there is only a significant association in the case of all population (r=0.102, p=0.011). body mass index in the two case and control groups had a significant difference (t=3.859, p=0.001). discussion : probability of cd should be considered since the prevalence of cd is high in patients with and beta-thalassemia major.  patients with thalassemia major are recommended to be screened for cd. keywords : celiac disease, beta-thalassemia major, growth disorder, disease risk, hla